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- ArticleRusso F, Santagati M, Santagati A, Arrigo Reina R.Farmaco Sci. 1978 Dec;33(12):972-83.The synthesis of derivatives of 5H-1,3,4-thiadiazolo[3,2-a]-s-triazine-5,7-dione substituted in position 2 and 6 is described. The compounds were subjected to pharmacological screening, and some were found to possess antiinflammatory and antipyretic properties.